Engineering the CNS stem cell microenvironment
نویسندگان
چکیده
منابع مشابه
Engineering the stem cell microenvironment.
Multipotent stem cells in the body facilitate tissue regeneration, growth, and wound healing throughout life. The microenvironment in which they reside provides signals that direct these progenitors to proliferate, differentiate, or remain dormant; these factors include soluble molecules, the extracellular matrix, neighboring cells, and physical stimuli. Recent advances in the culture of embryo...
متن کاملEngineering physical microenvironment for stem cell based regenerative medicine.
Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation effi...
متن کاملThe neural stem cell microenvironment∗
1. The embryonic neural stem cell (NSC) microenvironment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1. The VZ microenvironment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2. Signalling in the embryonic NSC microenvironment . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
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Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...
متن کاملCell patterning chip for controlling the stem cell microenvironment.
Cell-cell signaling is an important component of the stem cell microenvironment, affecting both differentiation and self-renewal. However, traditional cell-culture techniques do not provide precise control over cell-cell interactions, while existing cell-patterning technologies are limited when used with proliferating or motile cells. To address these limitations, we created the Bio Flip Chip (...
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ژورنال
عنوان ژورنال: Regenerative Medicine
سال: 2009
ISSN: 1746-0751,1746-076X
DOI: 10.2217/rme.09.62